The main access to Varzi is by the state road no. 461 of the Penice Pass, winding up the valley from Voghera.

The nearest motorway accesses are Casei Gerola (36 km away) or Casteggio (40 km away) on the A7 Milan-Genoa motorway and Voghera (32 km away) on the A21 Turin-Brescia motorway.

The nearest railway station is at Voghera (30 km), with which Varzi is connected by a public bus service (Faa).

Autolinee Sapo run bus services between Varzi and minor towns in the upper Staffora valley as well as Pavia and Milan.

Road distances in kms from: Voghera 30, Pavia 55, Milan 100, Turin 135, Genoa 110, Rome 575.